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Temporal Response to seasonal and pandemic H1N1 infection in human DCs - Donor2

ABSTRACT: An 8 hours timecourse was performed with human DCs infected either with A/California/7/2009 and A/Brevig Mission/1/1918 (pandemic) or A/New Caledonia/20/99 and A/Texas/36/91 seosonal.

ORGANISM(S): Homo sapiens

PROVIDER: GSE55277 | GEO | 2015/08/20

SECONDARY ACCESSION(S): PRJNA239172

REPOSITORIES: GEO

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Temporal Response to seasonal and pandemic H1N1 infection in human DCs- Donor 1

2015-08-20 | GSE55276 | GEO

Temporal Response to seasonal and pandemic H1N1 infection in human DCs - Donor2

Project description:An 8 hours timecourse was performed with human DCs infected either with A/California/7/2009 and A/Brevig Mission/1/1918 (pandemic) or A/New Caledonia/20/99 and A/Texas/36/91 seosonal. Human monocyte derived dendritic cells (DCs) were infected either with chicken egg grown A/California/7/2009, A/Brevig Mission/1/1918, A/New Caledonia/20/99or A/Texas/36/91. Samples were taken and fixed in RNA stabilizing regaent at 2, 2.7, 3.3, 4, 5, 6, 7 and 8 hours. Cells exposed to chicken egg alantoic fluid served as a control. Infections with A/California/7/2009, A/New Caledonia/20/99 or A/Texas/36/91 were carried out at a BSL2 enviroment. Infections with A/Brevig Mission/1/1918 were carried out in a BSL3 enviroment in parralel to the BSL2 infections with cells from the same donor and cell preparation.

2015-08-20 | E-GEOD-55277 | biostudies-arrayexpress

Temporal Response to seasonal and pandemic H1N1 infection in human DCs- Donor 1

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Temporal Response to seasonal and pandemic H1N1 infection in human DCs

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-08-20 | GSE55278 | GEO

Temporal Response to seasonal and pandemic H1N1 infection in human DCs

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-08-20 | E-GEOD-55278 | biostudies-arrayexpress

Acute host transcriptonal response to A/Texas/36/91 influenza and A/Texas/36/91 influenza containing the NS1 gene from r1918 in A549 cells

2012-05-14 | GSE37829 | GEO

2009 pandemic H1N1 virus causes disease and upregulation of genes related to inflammatory and immune response, cell death, and lipid metabolism in pigs

Project description:This study used virological, histological, and global gene expression data to compare the virulence of two 2009 pH1N1 isolates from human (A/California/04/2009) and swine (A/swine/Alberta/25/2009) to that of a 1918-like classical swine influenza virus (A/swine/Iowa/1930) in a pig model of infection. The overall goal of this study was to characterize the clinical, histological, virological and global gene expression responses to three distinct influenza A isolates in an experimental pig model of influenza infection. We compared the pathogenesis of two pH1N1 viruses, one derived from a human patient (A/CA/04/09 [CA09]) and the other from swine (A/swine/Alberta/25/2009 [Alb09]), with that of the 1918-like classical swine influenza virus (A/swine/Iowa/1930 [IA30]) in the pig model. Both pH1N1 isolates induced clinical symptoms such as coughing, sneezing, decreased activity, fever, and labored breathing in challenged pigs, but IA30 virus did not cause any clinical symptoms except fever. Although both the pH1N1 viruses and the IA30 virus caused lung lesions, the pH1N1 viruses were shed from the nasal cavities of challenged pigs whereas the IA30 virus was not. Microarray was used to assess global gene expression in the lungs at 3 and 5 days post-infection.

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Acute host transcriptonal response to r1918 influenza and r1918 influenza containing the NS1 gene from A/Texas/36/91 in A549 cells

2012-05-14 | GSE37951 | GEO

Acute host transcriptonal response to r1918 influenza and r1918 influenza containing the NS1 gene from A/Texas/36/91 in A549 cells

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