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Gene expression profiling of circulating tumor cells in breast cancer

ABSTRACT: CTCs are the purpoted intermediates of metastatic dissemination and are likely to contain cellular clones responsible for disease progression representing a preferred source for identification of druggable targets. Unfortunately a molecular characterization of CTCs is seriously hampered by their low numbers even in metastatic patients and by the elevated contamination of isolated CTCs with leukocytes. With the final goal of providing a reliable assay allowing to obtain valuable information on CTC features in the clinical setting, we have developed a method based on capture with beads linked to EpCAM and to MUC1 exploiting a commercially available kit and performing an extensive gene expression profiling with the DASL platform.

ORGANISM(S): Homo sapiens

PROVIDER: GSE55470 | GEO | 2014/11/21

SECONDARY ACCESSION(S): PRJNA239696

REPOSITORIES: GEO

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Gene expression profiling of circulating tumor cells in breast cancer

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