Epigenetic regulation of MYC modulates glioblastoma tumorigenicity
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ABSTRACT: One aspect of intra-tumoral heterogeneity in glioblastoma involves subpopulations of cells capable of self-renewal and indefinite propagation. Conceptually, this capacity is frequently treated as a static property. Here we provide data suggesting that tumorigenicity in glioblastomais a dynamic property that can be acquired or lost. Integrated expression analyses suggest that tumorigenicity is determined by the level of MYC expression relative to a threshold. Transitions between tumorigenic and non-tumorigenic cell states are associated with changes in histone modifications at the MYC locus, suggesting tumorigenicity is epigenetically regulated.
ORGANISM(S): Homo sapiens
PROVIDER: GSE56316 | GEO | 2014/03/28
SECONDARY ACCESSION(S): PRJNA242894
REPOSITORIES: GEO
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