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Deep sequencing identify small molecule modulated microRNAs in the J1 mESCs

ABSTRACT: Many small molecular compounds reported were involved in improving reprogramming efficiency during inducing pluripotent stem cells (iPSC) or maintain a blastocyst-like state in embryonic stem cells (ESC), including BIO, CHIR99021 (CHIR), and vitamin C et al. However, the knowledge about these small molecules regulating miRNAs in ESC was limited. To understand the role of miRNAs during small molecules induced ESC maintenance and gain an insight how these small molecules regulates miRNAs expression; we performed small RNA sequencing using Illumina HiSeq 2000 under the compounds treatment.The data show the miRNAs regulated by SB431542

ORGANISM(S): Mus musculus

PROVIDER: GSE56385 | GEO | 2015/06/01

SECONDARY ACCESSION(S): PRJNA243083

REPOSITORIES: GEO

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Deep sequencing identifies small molecule modulated microRNAs in the J1 mESCs

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