Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The epigenetic regulator Uhrf1 facilitates functional expansion of colonic regulatory T cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE56544 | GEO | 2014/04/07

SECONDARY ACCESSION(S): PRJNA243857

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

The epigenetic regulator Uhrf1 facilitates functional expansion of colonic regulatory T cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-04-07 | E-GEOD-56544 | biostudies-arrayexpress

Epigenetic regulator UHRF1 suppressively organize multiple pathogenesis in rheumatoid arthritis.

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-02-16 | GSE166748 | GEO

Decoding the regulatory circuit by epigenetic regulator MOF in haematopoiesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-03-13 | GSE107154 | GEO

UHRF1: a jack of all trades, and a master epigenetic regulator during spermatogenesis.

Project description: Not available

| S-EPMC7253785 | biostudies-literature

Commensal microbe-derived butyrate epigenetically induces colonic regulatory T cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-11-20 | E-GEOD-49655 | biostudies-arrayexpress

Isolation and in vitro expansion of human colonic stem cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2011-11-22 | GSE31257 | GEO

Evolution of Context Dependent Regulation by Expansion of Feast/Famine Regulatory Proteins

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-10-03 | E-GEOD-62052 | biostudies-arrayexpress

Regulatory T cells from colonic lamina propria

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-07-25 | GSE71316 | GEO

The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein.

Project description:The promyelocytic leukemia (PML) protein is a tumor suppressor originally identified in acute promyelocytic leukemia and implicated in tumorigenesis in multiple forms of cancer. Here, we demonstrate that the PML protein undergoes ubiquitination-mediated degradation facilitated by an E3 ligase UHRF1 (ubiquitin-like with PHD and RING finger domains 1), which is commonly upregulated in various human malignancies. Furthermore, UHRF1 negatively regulates PML protein accumulation in primary human umbilical vein endothelial cells (HUVECs), HEK 293 cells and cancer cells. Knockdown of UHRF1 upregulates whereas ectopic overexpression of UHRF1 downregulates protein abundance of endogenous or exogenous PML, doing so through its binding to the N-terminus of PML. Overexpression of wild-type UHRF1 shortens PML protein half-life and promotes PML polyubiquitination, whereas deletion of the RING domain or coexpression of the dominant-negative E2 ubiquitin-conjugating enzyme, E2D2, attenuates this modification to PML. Finally, knockdown of UHRF1 prolongs PML half-life and increases PML protein accumulation, yet inhibits cell migration and in vitro capillary tube formation, whereas co-knockdown of PML compromises this inhibitory effect. These findings suggest that UHRF1 promotes the turnover of PML protein, and thus targeting UHRF1 to restore PML-mediated tumor suppression represents a promising, novel, anticancer strategy.

| S-EPMC3578017 | biostudies-literature

The DNMT1 associated lncRNA Dali is an epigenetic regulator of neural differentiation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-12-03 | E-GEOD-62035 | biostudies-arrayexpress