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Commensal microbe-derived butyrate epigenetically induces colonic regulatory T cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Takaho Endo

PROVIDER: E-GEOD-49655 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.

Furusawa Yukihiro Y Obata Yuuki Y Fukuda Shinji S Endo Takaho A TA Nakato Gaku G Takahashi Daisuke D Nakanishi Yumiko Y Uetake Chikako C Kato Keiko K Kato Tamotsu T Takahashi Masumi M Fukuda Noriko N NN Murakami Shinnosuke S Miyauchi Eiji E Hino Shingo S Atarashi Koji K Onawa Satoshi S Fujimura Yumiko Y Lockett Trevor T Clarke Julie M JM Topping David L DL Tomita Masaru M Hori Shohei S Ohara Osamu O Morita Tatsuya T Koseki Haruhiko H Kikuchi Jun J Honda Kenya K Hase Koji K Ohno Hiroshi H

Nature 20131113 7480

Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. However, the molecular mechanisms by which commensal microbes induce colonic Treg cells have been unclear. Here we show that a large bowel microbial fermentation product, butyrate, induce ...[more]

PMID: 24226770

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