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Expression data from human breast cancer cells MDA-MB-231-Luc knockdown for RRAS2 expression.

ABSTRACT: We used microarrays to investigate gene expression changes induced by the inhibition of RRAS2 expression using shRNA techniques to stably knockdown the endogenous transcripts of this GTPase in human MDA-MB-231-Luc cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE56615 | GEO | 2014/04/09

SECONDARY ACCESSION(S): PRJNA244085

REPOSITORIES: GEO

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Expression data from human breast cancer cells MDA-MB-231-Luc knockdown for RRAS2 expression.

Project description:We used microarrays to investigate gene expression changes induced by the inhibition of RRAS2 expression using shRNA techniques to stably knockdown the endogenous transcripts of this GTPase in human MDA-MB-231-Luc cells. MDA-MB-231-Luc shControl (MDA-Control) and RRAS2-deficient (KDRRAS2.p1) in exponential growth phase were selected for RNA extraction and and hybridization on Affymetrix microarrays.

2014-04-09 | E-GEOD-56615 | biostudies-arrayexpress

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Project description:CD44, an adhesion molecule that binds to extracellular matrix, primarily to hyaluronan (HA), has been implicated in cancer cell migration, invasion, and metastasis. CD44 has also recently been recognized as a marker for stem cells of several types of cancer. However, the roles of CD44 in the development of bone metastasis still remain unclear. To explore this issue, we established the MDA-MB-231 human breast cancer cells stably expressing short hairpin RNA against CD44. The CD44-knockdown MDA-MB-231 cells (MDA-MB-231 shCD44-2 and shCD44-3) were analyzed. As control, MDA-MB-231 cells stably expressing shRNA against firefly luciferase (shLuc) were used. Total of three samples. No replicates.

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SUV420H2 over-expression affects on gene expression in human breast cancer MDA-MB-231 cells [MAA13355]

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Project description:Transcriptomes of MDA-MB-231 and LM2-4/luc+ human breast cancer cell-lines

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