Transcriptomics

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Gene expression profile in the lung of mice during pneumococcal pneumonia: WT vs NLRP3 inflammasome component-deficient mice


ABSTRACT: Inflammasomes are multiprotein platforms of caspase-1 activation. The NLRP3 inflammasome is composed of NLRP3, ASC, and procaspase-1. This inflammasome is activated by various endogenous and exogenous stimuli, including pneumococci, and protects from a variety of microbial pathogens. In the present study, we examined the role of NLRP3 inflammasome components in gene expression in the lung during pneumococcal pneumina.

ORGANISM(S): Mus musculus

PROVIDER: GSE56653 | GEO | 2014/12/31

SECONDARY ACCESSION(S): PRJNA244243

REPOSITORIES: GEO

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