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Expression profile of bcl11b-/- preselected DP thymocytes

ABSTRACT: Review on the role of Bcl11b in thymus and periphery and impact on diseases

ORGANISM(S): Mus musculus

PROVIDER: GSE56714 | GEO | 2014/04/12

SECONDARY ACCESSION(S): PRJNA244500

REPOSITORIES: GEO

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Expression profile of bcl11b-/- preselected DP thymocytes

Project description:Review on the role of Bcl11b in thymus and periphery and impact on diseases RNA was extracted from DP thymocytes of bcl11bf/fCd4cre/tcra-/- and tcra-/- mice. Tcra-/- mice only have preselected DP thymocytes. Such mice were used to determine the role of Bcl11b before selection, considering the defective positive selection in bcl11bf/fcd4cre mice. RNA was isolated and submitted for library generation and microarray analysis to determine expression profile of bcl11b-/- preselected DP thymocytes.

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