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Single cell gene expression profiling of bone marrow derived DN thymocytes from wild-type or Bcl11b timing enhancer deletion (ΔTE) mice.

ABSTRACT: Removing the Bcl11b timing enhancer delays Bcl11b activation and results in decreased T cell output and increased ILC production in the thymus. We used single cell RNA sequencing (scRNA-seq) to analyze the transcriptional programs that are altered and lead to increased ILC generation in Bcl11b ΔTE mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE282201 | GEO | 2024/11/20

REPOSITORIES: GEO

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