Transcriptomics

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Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution


ABSTRACT: The thymic microenvironment is essential for proper differentiation and selection of thymocytes.Thymic involution in aged mice results in decreased T cell output and immune function. Here we use gene expression profiling of FACS sorted thymic stromal subsets to identify molecular mediators of thymocyte: stromal cell interactions, as well as gene expression changes thymic stromal subsets during early stages of thymic involution . We used microarrays to analyze gene expression differences between thymic stromal subsets from male C57BL/6J mice 1, 3, and 6 months of age.

ORGANISM(S): Mus musculus

PROVIDER: GSE56928 | GEO | 2014/09/12

SECONDARY ACCESSION(S): PRJNA244976

REPOSITORIES: GEO

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