Transcriptomics

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Lung-resident myeloid-derived suppressor cells display dual functionality in experimental tuberculosis


ABSTRACT: Using cell-based approaches and experimental mouse models for pulmonary TB we unveiled MDSCs as new myeloid populations directly interacting with Mycobacterium tuberculosis (Mtb). MDSCs readily phagocytosed Mtb, released proinflammatory (IL-6, IL-1α) and immunomodulatory (IL-10) cytokines while retaining their suppressive capacity. MDSCs were identified at the site of infection in disease-resistant and -susceptible mice during pulmonary TB. Excessive MDSC accumulation in lungs correlated with elevated surface expression of IL-4Rα and heightened TB lethality.

ORGANISM(S): Mus musculus

PROVIDER: GSE57124 | GEO | 2014/12/21

SECONDARY ACCESSION(S): PRJNA245512

REPOSITORIES: GEO

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