Genomics

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MicroRNA expression profile in CHME3 cells infected with Japanese encephalitis virus


ABSTRACT: CHME3 cells grown on six-wells were infected with Japanese encephalitis virus (JEV) (P20778 strain), and total RNA was isolated from cells at 6, 24 and 48 h of post infection. MicroRNA expression was significantly altered in JEV-infected human microglial cells. A time-dependent change in microRNA profile was noted. Bioinformatics analysis identified anti-correlation between differentially expressed miRNAs and the gene expression at different time point which ultimately affected several signalling pathways in microglia cells. Brain-enriched microRNAs and a set of microRNA previously designated as NeurimmiRs were also differentially expressed in response to JEV infection.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE57410 | GEO | 2015/01/01

SECONDARY ACCESSION(S): PRJNA246404

REPOSITORIES: GEO

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