Genomics

Dataset Information

0

In vitro murine embryonic microRNA expression signatures predicting the non-genotoxic carcinogenic potential of chemicals


ABSTRACT: The human body is continuously exposed to various compounds that could initiate or accelerate cancer development. Such carcinogenic compounds can be classified into a genotoxic and non-genotoxic group. Especially carcinogenicity of non-genotoxic compounds is difficult to determine with current in vitro assessments and therefore has to be improved urgently. Here, we used a toxicogenomics-based approach by genome-wide microRNA expression profiling of mouse embryonic stem (mES) cells to identify microRNA classifiers for genotoxic carcinogens (GTXC), non-genotoxic carcinogens (NGTXC) and oxidative (Ox) compounds. We exposed mES cells to four different NGTXC, four GTXC and four Ox compounds. Differential microRNA expression was determined 4, 8 and 12 hours after exposure and was used to assess its discriminative power for NGTXC and GTXC. We generated an accurate classifier set, which was discriminative for NGTXC using a tiered approach. In conclusion, our study indicates that microRNA expression profiles can discriminate between NGTXC, GTXC and Ox compounds with high accuracy.

ORGANISM(S): Mus musculus Rattus norvegicus Homo sapiens

PROVIDER: GSE57839 | GEO | 2017/06/01

SECONDARY ACCESSION(S): PRJNA248294

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-06-28 | GSE72081 | GEO
2016-06-28 | GSE72014 | GEO
2014-04-01 | GSE43977 | GEO
2016-06-28 | E-GEOD-72014 | biostudies-arrayexpress
2016-06-28 | E-GEOD-72081 | biostudies-arrayexpress
2007-06-22 | E-GEOD-8251 | biostudies-arrayexpress
2014-04-01 | E-GEOD-43977 | biostudies-arrayexpress
2010-10-22 | GSE24891 | GEO
2004-03-08 | E-MEXP-89 | biostudies-arrayexpress
2010-10-22 | E-GEOD-24891 | biostudies-arrayexpress