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Expression data from chemokine-deficient mus musculus subjected to traumatic brain injury (TBI)

ABSTRACT: We inflicted TBI to chemokine-deficient mouse lines in order to establish involvement of various signalling pathways that may be addressed therapeutically. Interacting chemokine pathways in brain regulate distinct inflammatory cells. Activated microglia are separate from invading phagocytes and dendritic cells. Findings show potential targets to interfere with specific inflammatory responses after brain injury.

ORGANISM(S): Mus musculus

PROVIDER: GSE58483 | GEO | 2014/06/14

SECONDARY ACCESSION(S): PRJNA252734

REPOSITORIES: GEO

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Expression data from chemokine-deficient mus musculus subjected to traumatic brain injury (TBI)

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Expression data from mus musculus subjected to traumatic brain injury (TBI)

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Project description:Adult male and female w1118 flies were inflicted with traumatic brain injury using high-impact trauma device. Brains were dissected at control, 1, 2 and 4 hours post-TBI. Total RNA was extracted from fly brains and 3'mRNA-seq was performed to assess gene expression changes in response to TBI in both sexes. 3 replicates were sequenced for each condition.

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Hippocampus-Cerebellum Axis Specific Transcriptomic Stratification to Discriminate Mild from Moderate TBI

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