SM5-1-conjugated gold nanoparticles for antibody therapy in hepatocellular carcinoma
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ABSTRACT: As a humanized mouse antibody, SM5-1 can target a membrane protein of about 230kDa over-expressed in hepatocellular carcinoma (HCC), melanoma and breast cancer and it has been found to inhibit the progress of tumor cells. In this study, SM5-1 conjugated gold nanoparticles were prepared to study the antitumor efficacy in the treatment of HCC-LM3-fLuc tumor. The results showed that AU-SM5-1 could inhibit HCC-LM3 hepatocellular carcinoma cell proliferation up to 71.26% at the concentration of 0.5mg/ml contrast with SM5-1 and gold nanoparticles. In order to address the mechanism of the antiproliferative effects of AU-SM5-1, we examined the gene expression in HCC-LM3-fLuc tumor cells based on gene-chip screening.
ORGANISM(S): Homo sapiens
PROVIDER: GSE59284 | GEO | 2014/07/11
SECONDARY ACCESSION(S): PRJNA254956
REPOSITORIES: GEO
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