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MiRNA expression data from SOX2 knock-out 2102Ep and NTera-2 human embryonal carcinoma cell lines

ABSTRACT: SOX2 is an oncogene and a core pluripotency transcription factor. SOX2 has multiple roles in various malignancies, in the maintenance of pluripotency and during various stages of embryonic development. Human embryonal carcinoma cells express SOX2 and the loss of this results in their differentiation. We silenced SOX2 in two human embryonal carcinoma cell lines and measured the differential expression of 754 unique mature miRNAs. This revealed the deregulation of many oncomiRs, tumour suppressor miRNAs and developmental miRNAs, including those belonging to the C19MC cluster.

ORGANISM(S): Homo sapiens

PROVIDER: GSE59380 | GEO | 2014/08/15

SECONDARY ACCESSION(S): PRJNA255222

REPOSITORIES: GEO

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Gene expression data from SOX2 knock-out 2102Ep and NTera-2 human embryonal carcinoma cell lines

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