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Post-transcriptional regulation of circadian rhythm by miRNA in mouse liver

ABSTRACT: Gene regulatory circuit of circadian rhythm has been well studied at the transcriptional level. However, recent published Nascent-sequencing and proteomic data indicates that post-transcriptional mechanisms play essential roles in modulating temporal gene expression for proper circadian function. miRNAs are 19-25 nucleotides long small RNAs now well-known for their regulatory roles in the development and diseases through post-transcriptional and translational controls in a wide range of species. We systematically analyzed the miRNAs in mouse liver by Agilent microarray. Then by combining our results with the published high-through liver circadian microarray data, we identified nine mouse liver circadian miRNAs.

ORGANISM(S): Mus musculus

PROVIDER: GSE59423 | GEO | 2015/06/30

SECONDARY ACCESSION(S): PRJNA255284

REPOSITORIES: GEO

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Post-transcriptional regulation of circadian rhythm by miRNA in mouse liver

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