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Expression analysis of KHR and KR oral tumors with intact or deficient Notch1

ABSTRACT: KHR and KR tumors grow faster when deficient for Notch1. The hypothesis was to test for differences in gene expression between KHR and KHR oral tumors with intact or deficient Notch1 haplotypes.

ORGANISM(S): Mus musculus

PROVIDER: GSE59951 | GEO | 2015/09/09

SECONDARY ACCESSION(S): PRJNA257155

REPOSITORIES: GEO

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Expression analysis of KHR and KR oral tumors with intact or deficient Notch1

Project description:KHR and KR tumors grow faster when deficient for Notch1. The hypothesis was to test for differences in gene expression between KHR and KHR oral tumors with intact or deficient Notch1 haplotypes. Total RNA was isolated for KHR (n=5), KHR-N+/- (n=4), KHR-N-/- (n=5), KR-N+/- (n=5), KR-N-/- (n=4) oral tumors. Expression profiling was performed using the Illumina MouseRef-8 v2 (GPL6885) array. Studies were conducted using tumors from C57BL/6 mice.

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