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DNA methylation data from normal and chronic periodontitis patients from site OCI and USC

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE59962 | GEO | 2015/07/29

SECONDARY ACCESSION(S): PRJNA257184

REPOSITORIES: GEO

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DNA methylation data from normal and chronic periodontitis patients from site OCI and USC

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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DNA methylation data from 11 normal and 9 chronic periodontitis patients from site USC

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DNA methylation data from normal and chronic periodontitis patients from site OCI and USC

Project description:DNA methylation data from normal and chronic periodontitis patients from site OCI and USC

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Alteration of PTGS2 promoter methylation in chronic periodontitis.

Project description:Levels of prostaglandin E(2) and the prostaglandin-endoperoxide synthase-2 (PTGS2, or COX-2) increase in actively progressing periodontal lesions, but decrease in chronic disease. We hypothesized that chronic inflammation is associated with altered DNA methylation levels within the PTGS2 promoter, with effects on COX-2 mRNA expression. PTGS2 promoter methylation levels from periodontally inflamed gingival biopsies showed a 5.06-fold increase as compared with non-inflamed samples (p = 0.03), and the odds of methylation in a CpG site in the inflamed gingival group is 4.46 times higher than in the same site in the non-inflamed group (p = 0.016). The level of methylation at -458 bp was inversely associated with transcriptional levels of PTGS2 (RT-PCR) (p = 0.01). Analysis of the data suggests that, in chronically inflamed tissues, there is a hypermethylation pattern of the PTGS2 promoter in association with a lower level of PTGS2 transcription, consistent with a dampening of COX-2 expression in chronic periodontitis. These findings suggest that the chronic persistence of the biofilm and inflammation may be associated with epigenetic changes in local tissues at the biofilm-gingival interface.

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SUBGINGIVAL DYSBIOSIS IN CHRONIC PERIODONTITIS PATIENTS

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