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Gene expressions in pancreatic cancer cells

ABSTRACT: We used time-dependent spheroidal cultures of pancreatic cancer cells to investigate how spatiotemporal regulation in spheroids induces epithelial-mesenchymal plasticity (EMP). We generated a round bottom spheroidal model using β3 integrin-negative pancreatic cancer cells in 2D conventional monolayer cultures, and compared the expression of integrin signaling-related genes that induce spheroidal geometry to determine if spheroidal geometry induces integrin switching.

ORGANISM(S): Homo sapiens

PROVIDER: GSE60139 | GEO | 2014/08/06

SECONDARY ACCESSION(S): PRJNA257555

REPOSITORIES: GEO

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