Genome-wide expression analysis of mouse plasma cell tumors show importance of IL-6 in tumor development
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ABSTRACT: Interleukin 6 (IL-6) is a pro-inflammatory cytokine important for plasmacytomagenesis. Here we showed that the strom cell-derived IL-6 is critical for plasma cell tumors (PCTs). The gene expression analysis of mouse PCTs showed that adoptive-transfer PCT and spontaneous PCT have similar patterns. Further, the mouse tumors also illustrated resemblance to human multiple myeloma (MM).
ORGANISM(S): Mus musculus
PROVIDER: GSE60282 | GEO | 2015/07/27
SECONDARY ACCESSION(S): PRJNA257936
REPOSITORIES: GEO
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