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Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family in C. elegans [miRNA-Seq]

ABSTRACT: In animals, microRNAs frequently form families with related sequences. The functional relevance of miRNA families and the relative contribution of family members to target repression have remained, however, largely unexplored. Here, we used the C. elegans miR-58 miRNA family, comprised primarily of four highly abundant members: miR-58.1, miR-80, miR-81 and miR-82, as a model to investigate the redundancy of miRNA family members and their impact on target expression in an in vivo setting.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE60419 | GEO | 2015/06/05

SECONDARY ACCESSION(S): PRJNA258215

REPOSITORIES: GEO

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