Transcriptomics

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Lateral ventricle SVZ: 3xTg vs WT


ABSTRACT: Transcriptional profiling of the microdissected SVZ from 7-month-old mice Adult neurogenesis is suppressed in the SVZ of 3xTg mice, a model of Alzheimer's disease. To better understand the underlying mechanisms of this suppression, the goals of this experiment were to compare the transcriptional profiles of the SVZ neural stem cell niche in 3xTg-AD mice versus strain controls. We used early middle-aged mice (7-months-old) rather than old mice, in order to identify genetic changes that are not caused secondarily to other degenerative changes occurring in these mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE60460 | GEO | 2015/08/01

SECONDARY ACCESSION(S): PRJNA258324

REPOSITORIES: GEO

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