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Epigenome analysis of the human liver

ABSTRACT: Liver tissue samples were obtained from severely obese individuals that underwent bariatric surgery. The goal of this study was to identify tissue specific methylation QTLs. Whole-transcriptome subcutaneous adipose tissue methylation levels were determined in 67 individuals with a BMI >35 kg/m2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE61446 | GEO | 2014/09/17

SECONDARY ACCESSION(S): PRJNA261128

REPOSITORIES: GEO

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Epigenome analysis of the human liver

Project description:Liver tissue samples were obtained from severely obese individuals that underwent bariatric surgery. The goal of this study was to identify tissue specific methylation QTLs. Whole-transcriptome subcutaneous adipose tissue methylation levels were determined in 67 individuals with a BMI >35 kg/m2. Bisulphite converted DNA from the 67 Liver samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip

2014-09-17 | E-GEOD-61446 | biostudies-arrayexpress

Epigenome analysis of the human subqutaneous adipose tissue

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Epigenome analysis of the human visceral adipose tissue

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Epigenome analysis of the human subqutaneous adipose tissue

Project description:Subcutaneous adipose tissue samples were obtained from severely obese individuals that underwent bariatric surgery. The goal of this study was to identify tissue specific methylation QTLs. Whole-transcriptome subcutaneous adipose tissue methylation levels were determined in 71 individuals with a BMI >35 kg/m2. Bisulphite converted DNA from the 71 subcutaneous adipose tissue samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip.

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Project description:Subcutaneous adipose tissue and visceral adipose tissue samples were obtained from severely obese individuals that underwent bariatric surgery. The goal of this study was to compare genome-wide gene expression levels in the two tissue types from healthy and unhealthy severely obese individuals. Whole-transcriptome subcutaneous adipose tissue gene expression levels were determined in 73 individuals with a BMI >35 kg/m2. Whole-transcriptome visceral adipose tissue gene expression levels were determined in 69 individuals with a BMI >35 kg/m2. Modules of co-expressed genes likely to be functionally related were identfied and correlated with BMI, plasma levels of glucose, insulin, HbA1c, triglycerides, non-esterified fatty acids, ALAT, ASAT, C-reactive protein, and LDL- and HDL cholesterol.

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Expression data from Adipose Stem Cells (ASC) from morbidly obese and non-obese individuals

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