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Expression data from prostate tumors of TRAMPxPWK/PhJ F2 cross

ABSTRACT: We hypothesize that germline variation influences susceptibility to aggressive prostate tumor We examined the changes in gene expression in tumors obtained from TRAMPxPWK/PhJ F2 mice

ORGANISM(S): Mus musculus

PROVIDER: GSE61864 | GEO | 2015/12/15

SECONDARY ACCESSION(S): PRJNA262570

REPOSITORIES: GEO

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Expression data from prostate tumors of TRAMPxPWK/PhJ F2 cross

Project description:We hypothesize that germline variation influences susceptibility to aggressive prostate tumor We examined the changes in gene expression in tumors obtained from TRAMPxPWK/PhJ F2 mice Transgene-positive (Tg+) F2 males were bred by crossing Tg- sires to Tg+ dames. 27 tumor samples were analyzed, which were obtained from Tg+ F2 males

2015-12-15 | E-GEOD-61864 | biostudies-arrayexpress

Expression data from prostate tumor of TRAMPxNOD/ShiLtJ F2 cross

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Mouse F2 Cross, Carbohydrate Diet, Fat Tissue

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Project description:We profiled gene expression in hypothalamus tissue from F2 progeny from a cross between the outbred M16 (selectively bred for rapid weight gain) and ICR (control) mouse strains. We developed a framework for reconstructing tissue-to-tissue coexpression networks between genes in hypothalamus, liver or hypothalamus tissues that are independent of networks constructed from single tissue analyses. The subnetworks we identify as specific to tissue-to-tissue interactions associate with multiple obesity-relevant biological functions like circadian rhythm, energy balance, stress response, or immune response. Keywords: Tissue profiling in a mouse F2 cross.

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Project description:We profiled gene expression in adipose tissue from F2 progeny from a cross between the outbred M16 (selectively bred for rapid weight gain) and ICR (control) mouse strains. We developed a framework for reconstructing tissue-to-tissue coexpression networks between genes in hypothalamus, adipose or adipose tissues that are independent of networks constructed from single tissue analyses. The subnetworks we identify as specific to tissue-to-tissue interactions associate with multiple obesity-relevant biological functions like circadian rhythm, energy balance, stress response, or immune response. Keywords: Tissue profiling in a mouse F2 cross.

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Profiling of liver tissue from the F2 M16xICR mouse cross.

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Mouse F2 Cross, High Fat Diet, fat tissue

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2011-09-17 | E-MTAB-401 | biostudies-arrayexpress

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