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CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (TCRgd)

ABSTRACT: T lymphocytes are conventionally divided into subsets based upon expression of co-receptors, cytokines and surface molecules. By mRNA microarray analysis, T lymphocytes that express the C-type lectin CD161 were identified to share a transcriptional profile, which led to the identification of an innate function across these previously defined subsets, including CD8, CD4 and TCRgd T cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE62097 | GEO | 2014/10/07

SECONDARY ACCESSION(S): PRJNA263188

REPOSITORIES: GEO

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CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (TCRgd)

Project description:T lymphocytes are conventionally divided into subsets based upon expression of co-receptors, cytokines and surface molecules. By mRNA microarray analysis, T lymphocytes that express the C-type lectin CD161 were identified to share a transcriptional profile, which led to the identification of an innate function across these previously defined subsets, including CD8, CD4 and TCRgd T cells. Gene expression of sort purified, resting CD161+ and CD161- TCRgd T cells from peripheral blood was measured in 4 healthy donors.

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