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CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages

ABSTRACT: CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages

PROVIDER: PRJNA263184 | ENA |

REPOSITORIES: ENA

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CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (CD4)

Project description:T lymphocytes are conventionally divided into subsets based upon expression of co-receptors, cytokines and surface molecules. By mRNA microarray analysis, T lymphocytes that express the C-type lectin CD161 were identified to share a transcriptional profile, which led to the identification of an innate function across these previously defined subsets, including CD8, CD4 and TCRgd T cells. Gene expression of magnetically enriched, resting CD161+ and CD161- CD4+ T cells from peripheral blood was measured in 3 healthy donors.

2014-10-07 | E-GEOD-62095 | biostudies-arrayexpress

CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (TCRgd)

Project description:T lymphocytes are conventionally divided into subsets based upon expression of co-receptors, cytokines and surface molecules. By mRNA microarray analysis, T lymphocytes that express the C-type lectin CD161 were identified to share a transcriptional profile, which led to the identification of an innate function across these previously defined subsets, including CD8, CD4 and TCRgd T cells. Gene expression of sort purified, resting CD161+ and CD161- TCRgd T cells from peripheral blood was measured in 4 healthy donors.

2014-10-07 | E-GEOD-62097 | biostudies-arrayexpress

CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (CD 8)

Project description:T lymphocytes are conventionally divided into subsets based upon expression of co-receptors, cytokines and surface molecules. By mRNA microarray analysis, T lymphocytes that express the C-type lectin CD161 were identified to share a transcriptional profile, which led to the identification of an innate function across these previously defined subsets, including CD8, CD4 and TCRgd T cells. Gene expression of sort purified, resting CD161++, CD161+ and CD161- CD8+ T cells from peripheral blood was measured in 4 healthy donors.

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CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (TCRgd)

2014-10-07 | GSE62097 | GEO

CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (CD4)

2014-10-07 | GSE62095 | GEO

CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (CD 8)

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CD161+ Tconv and Treg share transcriptome and display a migratory phenotype which is modified at the inflamed site

Project description:Regulatory T cells (Treg) are a cornerstone of immune regulation. Recent evidence indicates that human Treg show plasticity in specific settings. A subpopulation of Treg expressing CD161, a marker associated with T helper (Th)17 cells, have T effector -like characteristics and are enriched at sites of autoimmune inflammation. Here we used RNAseq to confirm the effector-like signature of CD161+ Treg and demonstrated a shared transcriptional signature between CD161+ Treg and CD161+ conventional T cells (Tconv). Pathway analysis suggested that CD161+ T cells have a migratory phenotype, expressing high levels of CCR9 and integrin α4β7, markers associated with gut homing. In response to all-trans retinoic acid, CD161+ T cells expressed higher levels of CCR9 and integrin α4β7 than CD161- T cells. Our data suggest that blood CD161+ T cells may have adopted gut homing properties upon retinoic acid exposure. In contrast to their peripheral counterparts, CD161+ T cells from the site of autoimmune arthritis have a diminished gut homing phenotype and blunted response to retinoic acid. In health, the TCRβ repertoires of CD161+ and CD161- T cells showed limited overlap whereas there is clear overlap in T cell clones from synovial fluid of autoimmune arthritis patients. We therefore propose that CD161+ and CD161- T cells are largely distinct populations in the healthy immune system but that the inflamed site creates an environment where CD161 levels in T cells can be altered, potentially contributing to disease pathogenesis.

2017-03-27 | GSE86452 | GEO

CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-10-07 | E-GEOD-62099 | biostudies-arrayexpress

CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-10-07 | GSE62099 | GEO

CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.

Project description:The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all lineages, including a population known as mucosal-associated invariant T (MAIT) cells. To understand whether different T cell subsets expressing CD161 have similar properties, we examined these populations in parallel using mass cytometry and mRNA microarray approaches. The analysis identified a conserved CD161++/MAIT cell transcriptional signature enriched in CD161+CD8+ T cells, which can be extended to CD161+ CD4+ and CD161+TCRγδ+ T cells. Furthermore, this led to the identification of a shared innate-like, TCR-independent response to interleukin (IL)-12 plus IL-18 by different CD161-expressing T cell populations. This response was independent of regulation by CD161, which acted as a costimulatory molecule in the context of T cell receptor stimulation. Expression of CD161 hence identifies a transcriptional and functional phenotype, shared across human T lymphocytes and independent of both T cell receptor (TCR) expression and cell lineage.

| S-EPMC4250839 | biostudies-literature

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