Transcriptomics

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CHD8 controls progestin-dependent gene expression in T47D cells


ABSTRACT: CHD8 is an ATPase of the SNF2 family involved in ATP-dependent nucleosome remodeling. Our data indicate that in the presence of progestin (R5020), a progesterone receptor (PR) agonist, CHD8 is recruited to a number of PR enhancers. To correlate CHD8 binding sites with CHD8-regulated gene expression we performed a transcriptomic analysis of T47D-MTVL cells transfected with a control siRNA or a siRNA specifically targeting CHD8 and stimulated during 6h with progestin or vehicle. CHD8-dependent genes presented lower induction of up-regulated genes and lower repression of down-regulated genes, indicating that CHD8 is required for progesterone-dependent regulation of a subset of genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE62257 | GEO | 2015/06/01

SECONDARY ACCESSION(S): PRJNA263593

REPOSITORIES: GEO

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