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Expression data from muscle samples following synergist ablation

ABSTRACT: We used microarrays to detail the program of gene expression underlying the growth of the plantaris muscle following synergist ablation-induced supraphysiological overload

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE62388 | GEO | 2016/09/30

SECONDARY ACCESSION(S): PRJNA263966

REPOSITORIES: GEO

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Expression data during plantaris muscle hypertrophy with/without satellite cells induced by synergist ablation in young adult Pax7-DTA mice

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Expression data during plantaris muscle hypertrophy induced by synergist ablation in young adult mice

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Expression data during plantaris muscle hypertrophy induced by synergist ablation in young adult mice

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Project description:We report RNA sequencing data from the plantaris tendons of adult male mice in the C57Bl/6 background that either have the scleraxis gene (Scx+) or mice in which scleraxis has been deleted using CreERT2 driven from the Rosa26 locus (Scx-). Mice in which scleraxis was deleted were created by crossing scleraxis-floxed mice with Rosa26-CreERT2 mice. Rosa26-CreERT2 mice that did not have a floxed scleraxis allele served as controls. Mice were treated with tamoxifen for 5 days to induce recombination at the scleraxis locus, and then subjected to a synergist ablation procedure in which the Achilles tendon is removed, resulting in compensatory growth of the plantaris tendon. Mice were analyzed either 7 or 14 days after synergist ablation. Control mice that did not undergo tamoxifen treatment or synergist ablation were also studied (NOC).

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