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Expression data during plantaris muscle hypertrophy with/without satellite cells induced by synergist ablation in young adult Pax7-DTA mice

ABSTRACT: Global gene expression patterns were determined from microarray results from sham surgery or following 1 week of plantaris muscle hypertrophy induced by synergist ablation in young adult Pax7-DTA mice (4 months). Vehicle treated mice have their full complement of satellite cells; tamoxifen treated mice have had their satellite cells genetically depleted through Cre-loxP technology After sham surgery or 1 week of overload, Affymetrix chips (mouse430_2.0) were used with 1 µg of total RNA derived from a pooled sample of the right and left plantaris muscles from 11 animals.

ORGANISM(S): Mus musculus

SUBMITTER: Christopher Fry 

PROVIDER: E-GEOD-52597 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy.

Fry Christopher S CS   Lee Jonah D JD   Jackson Janna R JR   Kirby Tyler J TJ   Stasko Shawn A SA   Liu Honglu H   Dupont-Versteegden Esther E EE   McCarthy John J JJ   Peterson Charlotte A CA  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20131227 4

Our aim in the current study was to determine the necessity of satellite cells for long-term muscle growth and maintenance. We utilized a transgenic Pax7-DTA mouse model, allowing for the conditional depletion of > 90% of satellite cells with tamoxifen treatment. Synergist ablation surgery, where removal of synergist muscles places functional overload on the plantaris, was used to stimulate robust hypertrophy. Following 8 wk of overload, satellite cell-depleted muscle demonstrated an accumulatio  ...[more]

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