Hydrogen modulates signal transduction through manipulating oxidized phospholipid mediators
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ABSTRACT: We have previously demonstrated that molecular hydrogen (H2) neutralizes hydroxyl radical (•OH) in cultured-cells and protects cells and tissues against oxidative stress. Growing evidence has confirmed that H2-consumption exhibits preventive and therapeutic effects in patients with various diseases as well as model animals. Moreover, a small amount of H2 modulates signal transduction for regulating the expression of various genes; however, the primary target of H2 for exhibiting a variety of phenotypes was completely unknown. Here we show that H2 at low amounts manipulates oxidized phospholipid mediators to modulate Ca2+-signal transduction and gene expression.
ORGANISM(S): Homo sapiens
PROVIDER: GSE62434 | GEO | 2014/10/17
SECONDARY ACCESSION(S): PRJNA264091
REPOSITORIES: GEO
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