Genomics

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Genome-wide maps of Gata6 in primary mouse keratinocytes


ABSTRACT: In adult K14ΔNLef1 mouse, the overexpression of ∆NLef1, a ß-catenin dominat negative, in basal keratinocytes leads to the conversion of hair follicles into multilayered epithelial cysts and ectopic sebaceous gland. ∆NLef1 transcriptional activity led to Gata6 overexpression in the pilosebaceous unit in transgenic mice. To uncover direct target genes of Gata6 we performed ChIP-Seq experiments in primary mouse keratinocytes.

ORGANISM(S): Mus musculus

PROVIDER: GSE62607 | GEO | 2017/05/16

SECONDARY ACCESSION(S): PRJNA264535

REPOSITORIES: GEO

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