Transcriptomics

Dataset Information

0

SPR509: Lung metastasis


ABSTRACT: Determine gene expression differences between normal, metastatic and non-metastatic mouse lung tissue. Priming of the organ-specific premetastatic sites is thought to be an important yet incompletely understood step during metastasis. In this study, we show that the metastatic tumors we examined overexpress granulocyte-colony stimulating factor (G-CSF), which expands and mobilizes Ly6G+Ly6C+ granulocytes and facilitates their subsequent homing at distant organs even before the arrival of tumor cells. Moreover, G-CSF-mobilized Ly6G+Ly6C+ cells produce the Bv8 protein, which has been implicated in angiogenesis and mobilization of myeloid cells. Anti-G-CSF or anti-Bv8 antibodies significantly reduced lung metastasis. Transplantation of Bv8 null fetal liver cells into lethally irradiated hosts also reduced metastasis. We identified an unexpected role for Bv8: the ability to stimulate tumor cell migration through activation of one of the Bv8 receptors, prokineticin receptor (PKR)-1. Finally, we show that administration of recombinant G-CSF is sufficient to increase the numbers of Ly6G+Ly6C+ cells in organ-specific metastatic sites and results in enhanced metastatic ability of several tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE62817 | GEO | 2014/11/06

SECONDARY ACCESSION(S): PRJNA266417

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-11-06 | E-GEOD-62817 | biostudies-arrayexpress
2013-02-01 | E-GEOD-28408 | biostudies-arrayexpress
2015-04-01 | E-GEOD-65670 | biostudies-arrayexpress
2015-04-01 | GSE65670 | GEO
2022-05-16 | PXD013978 | Pride
2020-07-24 | E-MTAB-9128 | biostudies-arrayexpress
2018-10-03 | GSE118796 | GEO
2013-02-01 | GSE28408 | GEO
2019-06-26 | GSE123669 | GEO
| PRJNA150403 | ENA