MiR-487b, miR-3963 and miR-6412 delayed myogenic differentiation in C2C12 mouse myoblast-derived cells.
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ABSTRACT: We newly identified skeletal muscle differentiation-associated miRNAs by comparing miRNA expression profile between C2C12 cell and Wnt4-overexpressing C2C12 cell. miR-487b, miR-3963 and miR-6412 are significantly down-regulated in differentiating C2C12 cells, and transfection of their mimics resulted in reduced expression of myogenic differentiation markers including Troponin T, myosin heavy chain fast and slow type.
ORGANISM(S): Mus musculus
PROVIDER: GSE63454 | GEO | 2015/11/24
SECONDARY ACCESSION(S): PRJNA267828
REPOSITORIES: GEO
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