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Expression profiling of QSG-7701 and SMMC-7721 cells: stably express lncRNA-PRAL vs control

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE63600 | GEO | 2017/11/24

SECONDARY ACCESSION(S): PRJNA268371

REPOSITORIES: GEO

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Expression profiling of SMMC-7721 cells: stably express lncRNA-PRAL vs control

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Expression profiling of SMMC-7721 cells: stably express lncRNA-ATB vs pcDNA3.1

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Expression profiling of SMMC-7721 cells: stably express lncRNA-ATB vs pcDNA3.1

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2014-02-08 | E-GEOD-54798 | biostudies-arrayexpress

Expression profiling of SMMC-7721 cells: stably expressing lncRNA-hPVT1 vs LV-Control

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Expression profiling of SMMC-7721 cells: stably expressing lncRNA-hPVT1 vs LV-Control

Project description:In our present study, we found that lncRNA-hPVT1 could promote HCC cell proliferation. We want to know what were the target genes of lncRNA-hPVT1. So we constructed the hPVT1-overexpressed SMMC-771 cells and observed the mRNA profile in hPVT1-overexpressed and control SMMC-771 cells. lncRNA-hPVT1 induced transcriptional changes in SMMC-7721. Two-condition experiment, control (LV-Control) vs lncRNA-hPVT1 expression (LV-hPVT1 Clone2 ). Each has 3 biological repeats.

2014-05-20 | E-GEOD-57786 | biostudies-arrayexpress

Expression profiling of QSG-7701 and SMMC-7721 cells: stably express lncRNA-PRAL vs control

Project description:Expression profiling of QSG-7701 and SMMC-7721 cells: stably express lncRNA-PRAL vs control

| PRJNA268371 | ENA

Expression profiling of QSG-7701 cells: stably express lncRNA-PRAL vs control

Project description:lncRNA-PRAL induced transcriptional changes in QSG-7701

2017-11-24 | GSE63598 | GEO

Protein profile of human hepatocarcinoma cell line SMMC-7721: identification and functional analysis.

Project description:AIM:To investigate the protein profile of human hepatocarcinoma cell line SMMC-7721, to analyze the specific functions of abundant expressed proteins in the processes of hepatocarcinoma genesis, growth and metastasis, to identify the hepatocarcinoma-specific biomarkers for the early prediction in diagnosis, and to explore the new drug targets for liver cancer therapy. METHODS:Total proteins from human hepatocarcinoma cell line SMMC-7721 were separated by two-dimensional electrophoresis (2DE). The silver-stained gel was analyzed by 2DE software Image Master 2D Elite. Interesting protein spots were identified by peptide mass fingerprinting based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) and database searching. RESULTS:We obtained protein profile of human hepatocarcinoma cell line SMMC-7721. Among the twenty-one successfully identified proteins, mitofilin, endoplasmic reticulum protein ERp29, ubiquinol-cytochrome C reductase complex core protein I, peroxisomal enoyl CoA hydratase, peroxiredoxin-4 and probable 3-oxoacid CoA transferase 1 precursor were the six novel proteins identified in human hepatocarcinoma cells or tissues. Specific functions of the identified heat-shock proteins were analyzed in detail, and the results suggested that these proteins might promote tumorigenesis via inhibiting cell death induced by several cancer-related stresses or via inhibiting apoptosis at multiple points in the apoptotic signal pathway. Other identified chaperones and cancer-related proteins were also analyzed. CONCLUSION:Based on the protein profile of SMMC-7721 cells, functional analysis suggests that the identified chaperones and cancer-related proteins have their own pathways to contribute to the tumorigenesis, tumor growth and metastasis of liver cancer. Furthermore, proteomic analysis is indicated to be feasible in the cancer study.

| S-EPMC4146824 | biostudies-literature

Expression data from SMMC-7721 cells

Project description:We performed a genome wide transcription profile analysis to determine the expression alterations between control and the POH1 siRNAs transfected SMMC-7721 cells

2015-01-23 | GSE65210 | GEO

Folate-functionalized SMMC-7721 liver cancer cell membrane-cloaked paclitaxel nanocrystals for targeted chemotherapy of hepatoma.

Project description:In this study, we prepared a folic acid-functionalized SMMC-7721 liver cancer cell membrane (CM)-encapsulated paclitaxel nanocrystals system (FCPN) for hepatoma treatment. Transmission electron microscopy (TEM) characterization showed that FCPN was irregular spherical shapes with a particle size larger than 200 nm and a coated thickness of approximately 20 nm. In an in vitro release experiment, FCPN indicated a slowly release effect of paclitaxel (PTX). Cell experiments demonstrated that FCPN was taken up by SMMC-7721 cells and significantly inhibited the proliferation of SMMC-7721 cells, which illustrated that FCPN had good targeting ability compared with PN and CPN. According to the results of in vivo animal experiments, FCPN significantly inhibited tumor growth. Tissue distribution experiments proved that FCPN could accumulate significantly in tumor tissues, which further explained why FCPN had good targeting ability. These results clearly suggested that folate-functionalized homotypic CM bionic nanosystems might represent a very valuable method for liver cancer treatment in the future.

| S-EPMC8725828 | biostudies-literature

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