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Global re-wiring of p53 transcription regulation by the hepatitis B virus X (HBx) protein [Agilent]

ABSTRACT: As HBx has been reported to interact with p53 and alter the recruitment of p53 to its binding sites, we would like to identify p53-associated genes that were deregulated by HBx. We employed whole genome microarray expression profiling to identify genes that were deregulated by HBx protein.

ORGANISM(S): Homo sapiens

PROVIDER: GSE64875 | GEO | 2016/06/22

SECONDARY ACCESSION(S): PRJNA272432

REPOSITORIES: GEO

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Global re-wiring of p53 transcription regulation by the hepatitis B virus X (HBx) protein [ChIP-Seq]

Project description:As HBx has been reported to interact with p53 and alter the recruitment of p53 to its binding sites, we obtained a comprehensive genome-wide profile of deregulated p53 transcription complex-DNA binding by the HBx protein using massively parallel deep sequencing coupled to p53 chromatin immunoprecipitation (ChIP-Seq) on HBx-expressing and control HepG2 liver cell culture model system.

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