Transcriptome study of colon epithelial cells in Reg3a-transgenic mice

ABSTRACT: The human C-type lectin Reg3a (HIP/PAP) is an antimicrobial peptide that kills Gram-positive bacteria. Reg3a preserves gut microbiota homeostasis, reinforces intestinal barrier function and thereby helps to fight induced colitis in mice. Transcriptomic data revealed an upregulation of numerous genes involved in the robustness of the intestinal barrier, and the biosynthesis pathway of mucin core 1 and 3 O-glycans.

ORGANISM(S): Mus musculus

PROVIDER: GSE64932 | GEO | 2018/01/31

REPOSITORIES: GEO