Transcriptomics

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Ovalbumin sensitized and challenged induces differential gene expression in mouse lungs


ABSTRACT: To gain insight into the promoting effect of ultrafine particle inhalation on development and progression of allergic asthma, we selected an experimental approach involving exposure to ultrafine carbon particles (UCP) and gene expression profiling of lungs from mice with experimental, ovalbumin induced allergy. Comparative gene expression analysis was performed by hybridizing pooled cDNA samples from lavaged lungs of different groups. These results suggest that allergic sensitization may represent a susceptibility factor for effects of UCP on gene expression in the lung. In sensitized individuals UCP exposure, such as found in polluted air, thus may contribute to the development and /or aggravation of allergic asthma. Keywords: Particle Inhalation, lung, ovalbumin sensitzed and challanged, experssion profiling

ORGANISM(S): Mus musculus

PROVIDER: GSE6496 | GEO | 2007/07/01

SECONDARY ACCESSION(S): PRJNA98667

REPOSITORIES: GEO

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