Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human induced Pluripotent stem cells: Normal diploid line vs lines with deletions of Chr7

ABSTRACT: Mapping deletions of Chr7 in human iPSC derived from patients cells through reprogramming

ORGANISM(S): Homo sapiens

PROVIDER: GSE65387 | GEO | 2015/02/16

SECONDARY ACCESSION(S): PRJNA273867

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Human Pluripotent stem cells: Normal diploid line vs lines with deletions of Chr7

Project description:Mapping deletions of Chr7 in human iPSC and ESCs derived from patients cells through reprogramming or chromosome engineering

2015-02-16 | GSE65386 | GEO

Human Pluripotent stem cells: Normal diploid line vs lines with deletions of Chr7

Project description:Mapping deletions of Chr7 in human iPSC and ESCs derived from patients cells through reprogramming or chromosome engineering Two-condition experiment, normal diploid hPSCs vs del7q-hPSCs

2015-02-16 | E-GEOD-65386 | biostudies-arrayexpress

Human induced Pluripotent stem cells: Normal diploid line vs lines with deletions of Chr7

Project description:Mapping deletions of Chr7 in human iPSC derived from patients cells through reprogramming Two-condition experiment, normal diploid iPSCs vs del7q-iPSCs

2015-02-16 | E-GEOD-65387 | biostudies-arrayexpress

Pluripotent stem cells: Normal diploid line vs lines with deletions of Chr7

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-02-16 | GSE65410 | GEO

Pluripotent stem cells: Normal diploid line vs lines with deletions of Chr7

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-02-16 | E-GEOD-65410 | biostudies-arrayexpress

Human induced pluripotent stem cells: diploid, chr7q deletion, spontaneous chr7 correction

Project description:Gene expression analysis, a) comparing isogenic karyotypically normal iPSCs to del7q-iPSCs, b) comparing del7q-iPSCs to spontaneously corrected iPSCs. The chr7q deletion results in reduced expression levels of a large number of genes in the chr7q deleted region Two-condition experiment, del7q-iPSCs vs. isogenic normal iPSCs and del7q-iPSCs vs spontaneously corrected-iPSCs. Biological replicates: 3 control replicates, 3 del7q-iPSC replicates and 3 spontaneously corrected-iPSC replicates

2015-02-16 | E-GEOD-65215 | biostudies-arrayexpress

Synaptic dysfunction in human neurons with Autism associated deletions in PTCHD1-AS

Project description:The Xp22.11 locus that encompasses PTCHD1, DDX53, and the long noncoding RNA (lncRNA) PTCHD1-AS is frequently disrupted in males with autism spectrum disorder (ASD), but the functional consequences of these genetic risk factors for ASD are unknown. : iPSC-derived neurons from the ASD subjects exhibited reduced miniature excitatory post-synaptic current (mEPSC) frequency and NMDA receptor hypofunction. We found that 35 ASD-associated deletions mapping to the PTCHD1 locus disrupt exons of PTCHD1-AS. We also report a novel ASD-associated deletion of PTCHD1-AS exon 3, and we show exon 3 loss alters PTCHD1-AS splicing without affecting expression of the neighboring PTCHD1 coding gene. Finally, targeted disruption of PTCHD1-AS exon 3 recapitulated diminished mEPSC frequency, supporting a role for the lncRNA in the etiology of ASD. Our genetic findings provide strong evidence that PTCHD1-AS deletions are risk factors for ASD, and human iPSC-derived neurons implicate these deletions in the neurophysiology of excitatory synapses and in ASD-associated synaptic impairment.

2019-09-03 | GSE129808 | GEO

RNA-seq of yeast with human chr7 YACs

Project description:RNA-seq was performed of S. cerevisiae harboring human chr7 YACs in order to gauge the frequency and form of transcription in naïve DNA (i.e. DNA that did not evolve in the host cell)

2022-11-15 | GSE217781 | GEO

Mapping of microhomologies at CRISPR/Cas9 deletions

Project description:Mapping of microhomologies at CRISPR/Cas9 deletions

| PRJNA540816 | ENA

Human induced pluripotent stem cells: diploid, chr7q deletion, spontaneous chr7 correction

2015-02-16 | GSE65215 | GEO