Expression data from breast cancer bone metastasis [MDA-MB 231 scp1833]
Ontology highlight
ABSTRACT: The goal of this study was to evaluate genes that are differentially expressed in the bone stroma when breast cancer metastasis are present. We focused our attention on bone stroma cells to understand how the dissemination and growth of tumor cells can impact on the bone environment. Moreover, we aimed to identify potential targets to inhibit the cross talk between cancer cells and tumor microenvironment in bone metastasis. MDA-MB 231 scp1833 breast cancer cell line were engineered to express luciferase and GFP, and injected in NOD-SCID mice by the intracardiac route to obtain bone metastasis. Tumor growth was monitored in-vivo by bioluminescence for 2 weeks. Endothelial cells and osteoblasts were isolated from the long bones of tumor-bearing and tumor-free mice to identify genes differentially expressed.
ORGANISM(S): Mus musculus
PROVIDER: GSE66204 | GEO | 2017/02/23
SECONDARY ACCESSION(S): PRJNA276105
REPOSITORIES: GEO
ACCESS DATA