Genomics

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X-CGD iPS cells before and after genome editing by designer nucleases


ABSTRACT: X-CGD (X-linked chronic granulomatous disease) patient derived CD34+ cells were reprogrammed into two X-CGD iPSC clones (7 and 25) and subsequently corrected using ZFN (clone 7) and TALEN (clone 25) by integrating a therapeutic gp91phox expression cassette into the AAVS1 "safe harbor" locus

ORGANISM(S): Homo sapiens

PROVIDER: GSE66337 | GEO | 2015/02/28

SECONDARY ACCESSION(S): PRJNA276663

REPOSITORIES: GEO

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