Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Agilent-custom CGH microarray analysis of hematological malignancies [copy number]

ABSTRACT: copy number analysis

ORGANISM(S): Homo sapiens

PROVIDER: GSE66958 | GEO | 2015/06/01

SECONDARY ACCESSION(S): PRJNA278471

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Agilent-custom CGH microarray analysis of hematological malignancies [copy number and loss of heterozygosity]

Project description:Copy number analysis and loss of homozygosity mapping

2015-06-01 | GSE66959 | GEO

Agilent-custom CGH microarray analysis of hematological malignancies

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-06-01 | GSE66960 | GEO

NeuroArray, A Custom CGH Microarray to Decipher Copy Number Variants in Alzheimer's Disease.

Project description:BackgroundCopy Number Variants (CNVs) represent a prevailing type of structural variation (deletions or duplications) in the human genome. In the last few years, several studies have demonstrated that CNVs represent significant mutations in Alzheimer's Disease (AD) hereditability. Currently, innovative high-throughput platforms and bioinformatics algorithms are spreading to screening CNVs involved in different neurological diseases. In particular, the use of custom arrays, based on libraries of probes that can detect significant genomic regions, have greatly improved the resolution of targeted regions and the identification of chromosomal aberrations.ObjectiveIn this work, we report the use of NeuroArray, a custom CGH microarray useful to screening and further investigate the role of the recurring genomic aberrations in patients with confirmed or suspected AD.MethodsThe custom oligonucleotide aCGH design includes 641 genes and 9118 exons, linked to AD. The genomic DNA was isolated from blood samples of AD affected patients. The entire protocol of custom NeuroArray included digestion, labelling and hybridization steps as a standard aCGH assay.ResultsThe NeuroArray analysis revealed the presence of amplifications in several genes associated with AD. In the coding regions of these genes, 14,586 probes were designed with a 348 bp median probe spacing. The majority of targeted AD genes map on chromosomes 1 and 10. A significant aspect of the NeuroArray design is that 95% of the total exon targets is covered by at least one probe, a resolution higher than CGH array platforms commercially available.ConclusionBy identifying with a high sensitivity the chromosomal abnormalities in a large panel of AD-related genes and other neurological diseases, the NeuroArray platform is a valid tool for clinical diagnosis.

| S-EPMC6128388 | biostudies-literature

caArray_socci-00214: TCGA Analysis of Copy Number for OV Using Agilent Human Genome CGH Microarray Kit 244K

Project description:TCGA Analysis of Copy Number for OV Using Agilent Human Genome CGH Microarray Kit 244K

2016-12-07 | GSE90928 | GEO

Gene copy number variation profiling by microarray

Project description:Gene copy number variation profiling by microarray

| PRJNA712994 | ENA

Copy number of oral cell lines [CGH]

Project description:Profiling of copy number mutations in commonly used non-cancerous oral cell lines

2014-07-15 | GSE59406 | GEO

Great Ape Copy Number Variation

Project description:Great Ape Copy Number Variation

| PRJNA144461 | ENA

Agilent custom 244K array CGH data for the HuRef individual

Project description:The ideal genome sequence for medical interpretation is complete and diploid, capturing the full spectrum of genetic variation. Toward this end, there has been progress in discovery of single nucleotide polymorphism (SNP) and small (<10bp) insertion/deletions (indels), but annotation of larger structural variation (SV) including copy number variation (CNV) has been less comprehensive, even with available diploid sequence assemblies. We applied a multi-step sequence and microarray-based analysis to identify numerous previously unknown SVs within the first genome sequence reported from an individual.

2013-02-12 | GSE20287 | GEO

Agilent custom 24M array CGH data for the HuRef individual

2013-02-12 | GSE20288 | GEO

Ty Copy Number Control

Project description:Evolution of transposable element copy number control in yeast

| PRJEB33725 | ENA