Transcriptomics

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STAT1 signaling in astrocytes is essential for control of infection in the central nervous system


ABSTRACT: The local production of IFN-γ is important to control Toxoplasma gondii in the brain but the basis for these protective effects are not fully understood. The studies presented here reveal that the ability of IFN-γ to inhibit parasite replication in astrocytes in vitro is dependent on signal transducer and activator of transcription 1 (STAT1) and that mice that specifically lack STAT1 in astrocytes are unable to limit parasite replication in the central nervous system (CNS). This susceptibility is associated with a loss of anti-microbial pathways but also altered local immune responses that include decreased T cell production of IFN-γ and elevated expression of inhibitory receptors. These results identify a critical role for astrocytes in limiting the replication of an important opportunistic pathogen and highlight their role in coordinating local anti-parasitic responses.

ORGANISM(S): Mus musculus

PROVIDER: GSE67137 | GEO | 2016/10/20

SECONDARY ACCESSION(S): PRJNA279073

REPOSITORIES: GEO

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