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Expression data from spontaneous highly maligant murine pre B cell lymphomas

ABSTRACT: In 20% of IRF4 deficient mice older than 150 days, spontaneous highly malignant pre B cell lymphomas emerge. A change in the expression profile of genes involved in tumor progession and malignancy is sought for by microarray analyses. We used microarrays to detail the global programme of gene expression underlying tumor development and identified distinct classes of up-regulated and downregulated genes in the spontaneous highly malignant pre B cell lymphoma.

ORGANISM(S): Mus musculus

PROVIDER: GSE67161 | GEO | 2015/05/01

SECONDARY ACCESSION(S): PRJNA279142

REPOSITORIES: GEO

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Expression data from spontaneous highly maligant murine pre B cell lymphomas

Project description:In 20% of IRF4 deficient mice older than 150 days, spontaneous highly malignant pre B cell lymphomas emerge. A change in the expression profile of genes involved in tumor progession and malignancy is sought for by microarray analyses. We used microarrays to detail the global programme of gene expression underlying tumor development and identified distinct classes of up-regulated and downregulated genes in the spontaneous highly malignant pre B cell lymphoma. Tumor mouse cells, control mouse B cells lacking IRF4 and control wildtype mouse B cells were purified for RNA extraction and hybridization on Affymetrix microarrays. We sought to obtain the different expression levels of genes in tumor cells vs. control cells in order to find specific tumor regulated genes. To that end, we used cells from murine tumors, control mouse B cells lacking IRF4 from bone marrow and sorted accourding to CD19+, sIgM- (control mice IRF4 Knockout ), and control wildtype mouse B cells from bone marrow sorted accourding to CD19+, CD25+, sIgM- (control mice wildtype C57Bl6).

2015-05-01 | E-GEOD-67161 | biostudies-arrayexpress

Global gene expression profiling of spontaneous mesotheliomas in F344N rats

Project description:Aged male Fischer 344/N rats are prone to developing spontaneous peritoneal mesotheliomas, which arise predominantly from the tunica vaginalis of the testes. A definitive cause for the predominance of this neoplasm in F344/N rats is unknown. Investigation of the molecular alterations that occur in spontaneous rat mesotheliomas may provide insight into their pathogenesis, as well enable a better understanding regarding the mechanisms underlying chemically induced mesothelioma in rodents. Mesothelial cell function represents a complex interplay of pathways related to host defense mechanisms and maintenance of cellular homeostasis. Global gene expression profiles of spontaneous mesotheliomas from vehicle control male F344/N rats from two-year National Toxicology Program carcinogenicity bioassays were analyzed to determine the molecular features of these tumors, and elucidate tumor-specific gene expression profiles. The resulting gene expression pattern showed that spontaneous mesotheliomas are associated with upregulation various growth factors, oncogenes, cytokines, pattern recognition response receptors (PRR) and pathogen associated molecular patterns (PAMP) receptors, and the production of reactive oxygen and nitrogen species, as well as downregulation of apoptosis pathways. Alterations in these pathways in turn trigger molecular responses that stimulate cell proliferation and promote tumor survival and progression. Five spontaneous malignant mesotheliomas from two-year-old F344/N rats and six normal Fred-PE mesothelial cell culture samples (as controls).

2013-09-06 | E-GEOD-47581 | biostudies-arrayexpress

Mus musculus

Project description:Expression data from spontaneous highly maligant murine pre B cell lymphomas

| PRJNA279142 | ENA

Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells

Project description:Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells

| PRJNA422050 | ENA

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

Project description:This SuperSeries is composed of the following subset Series: GSE38232: HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [gene expression] GSE38901: HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [ChIP-Seq] Refer to individual Series

2012-08-06 | E-GEOD-38912 | biostudies-arrayexpress

Spontaneous Tfh cells in lupus mice vs B6/J

Project description:Autoimmune T follicular helper (Tfh) cells have different properties from B6/J nonautoimmune tfh cells. To compare differences in Tfh cells due to ongoing SLE disease, spontaneous splenic Tfh (CD4+CXCR5+PD-1+) were cell sorted from a pre-enriched population of negatively isolated total CD4 cells by autoMACS. New zealand derived triple congenic lupus strain was compared with B6/J. RNA was immediately extracted with no culturing or treatment of cells.

2018-05-01 | GSE106455 | GEO

Expression data from mouse ovarian surface epithelium cells at different stages of malignancy

Project description:Ovarian cancer is one of the most deadly cancers accounting for only 3% of diagnosed cancers, but is the fifth leading cause of cancer deaths among woman; however, the progression of ovarian cancer is poorly understood. To study and further understand the early events that lead to epithelial derived ovarian cancer, we previously developed a cell model of progressive ovarian cancer. Mouse ovarian surface epithelial (MOSE) cells have undergone spontaneous transformation in cell culture and represent pre-neoplastic, non-tumorigenic to an aggressive malignant phenotype. Microarray analysis was performed with RNA isolated from different stages of MOSE cells to examine changes in gene expression as MOSE cells transition from a pre-neoplastic to a malignant state. RNA was isolated from MOSE early cell representing a pre-neoplastic, non-malignant stage, MOSE Intermediate cells representing a noeplastic, pre-invasive state, and MOSE Late cells representing a malignant, invasive stage. Three biological replicates were used to take into account variations within the heterogeneous cultures.

2011-03-03 | E-GEOD-24789 | biostudies-arrayexpress

Biochemistry of spontaneous preterm birth

Project description:Biochemistry of spontaneous preterm birth

| PRJNA493125 | ENA

Mycoplasma agalactiae enrofloxacin spontaneous mutants

Project description:Mycoplasma agalactiae enrofloxacin spontaneous mutants

| PRJEB28036 | ENA

Mouse placenta in spontaneous abortion

Project description:Genetic profiles of mouse placenta were examined especially at the implantation sites of causing spontaneous abortion at day 14.5 of pregnancy. There is a number of the suffered patients from the recurrent spontaneous abortion by unknown causes. It is an important process to understand genetic profiles in the abortion placentas for the investigation of specific causes to induce rejection of normal embryos from the maternal attack. Our study was carried out on the laboratory mice targeted spontaneous abortion to approximate human disease models.

2010-08-21 | GSE23737 | GEO

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