Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA279142 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Expression data from murine BRD2-mediated lymphomas
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Project description:RNA sequencing of Mus musculus thymic lymphomas
2019-06-06 | GSE85894 | GEO
Project description:In 20% of IRF4 deficient mice older than 150 days, spontaneous highly malignant pre B cell lymphomas emerge. A change in the expression profile of genes involved in tumor progession and malignancy is sought for by microarray analyses. We used microarrays to detail the global programme of gene expression underlying tumor development and identified distinct classes of up-regulated and downregulated genes in the spontaneous highly malignant pre B cell lymphoma.
2015-05-01 | GSE67161 | GEO
Project description:In 20% of IRF4 deficient mice older than 150 days, spontaneous highly malignant pre B cell lymphomas emerge. A change in the expression profile of genes involved in tumor progession and malignancy is sought for by microarray analyses. We used microarrays to detail the global programme of gene expression underlying tumor development and identified distinct classes of up-regulated and downregulated genes in the spontaneous highly malignant pre B cell lymphoma. Tumor mouse cells, control mouse B cells lacking IRF4 and control wildtype mouse B cells were purified for RNA extraction and hybridization on Affymetrix microarrays. We sought to obtain the different expression levels of genes in tumor cells vs. control cells in order to find specific tumor regulated genes. To that end, we used cells from murine tumors, control mouse B cells lacking IRF4 from bone marrow and sorted accourding to CD19+, sIgM- (control mice IRF4 Knockout ), and control wildtype mouse B cells from bone marrow sorted accourding to CD19+, CD25+, sIgM- (control mice wildtype C57Bl6).
2015-05-01 | E-GEOD-67161 | biostudies-arrayexpress
Project description:RNA sequencing of Mus musculus thymic lymphomas
2020-12-30 | GSE121739 | GEO
Project description:We collected whole genome testis expression data from hybrid zone mice. We integrated GWAS mapping of testis expression traits and low testis weight to gain insight into the genetic basis of hybrid male sterility.
2014-12-04 | GSE61417 | GEO
Project description:Introgressed variants from other species can be an important source of genetic variation because they may arise rapidly, can include multiple mutations on a single haplotype, and have often been pretested by selection in the species of origin. Although introgressed alleles are generally deleterious, several studies have reported introgression as the source of adaptive alleles-including the rodenticide-resistant variant of Vkorc1 that introgressed from Mus spretus into European populations of Mus musculus domesticus. Here, we conducted bidirectional genome scans to characterize introgressed regions into one wild population of M. spretus from Spain and three wild populations of M. m. domesticus from France, Germany, and Iran. Despite the fact that these species show considerable intrinsic postzygotic reproductive isolation, introgression was observed in all individuals, including in the M. musculus reference genome (GRCm38). Mus spretus individuals had a greater proportion of introgression compared with M. m. domesticus, and within M. m. domesticus, the proportion of introgression decreased with geographic distance from the area of sympatry. Introgression was observed on all autosomes for both species, but not on the X-chromosome in M. m. domesticus, consistent with known X-linked hybrid sterility and inviability genes that have been mapped to the M. spretus X-chromosome. Tract lengths were generally short with a few outliers of up to 2.7 Mb. Interestingly, the longest introgressed tracts were in olfactory receptor regions, and introgressed tracts were significantly enriched for olfactory receptor genes in both species, suggesting that introgression may be a source of functional novelty even between species with high barriers to gene flow.
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Project description:Translational research is commonly performed in the C57B6/J mouse strain, chosen for its genetic homogeneity and phenotypic uniformity. Here, we evaluate the suitability of the white-footed deer mouse (Peromyscus leucopus) as a model organism for aging research, offering a comparative analysis against C57B6/J and diversity outbred (DO) Mus musculus strains. Our study includes comparisons of body composition, skeletal muscle function, and cardiovascular parameters, shedding light on potential applications and limitations of P. leucopus in aging studies. Notably, P. leucopus exhibits distinct body composition characteristics, emphasizing reduced muscle force exertion and a unique metabolism, particularly in fat mass. Cardiovascular assessments showed changes in arterial stiffness, challenging conventional assumptions and highlighting the need for a nuanced interpretation of aging-related phenotypes. Our study also highlights inherent challenges associated with maintaining and phenotyping P. leucopus cohorts. Behavioral considerations, including anxiety-induced responses during handling and phenotyping assessment, pose obstacles in acquiring meaningful data. Moreover, the unique anatomy of P. leucopus necessitates careful adaptation of protocols designed for Mus musculus. While showcasing potential benefits, further extensive analyses across broader age ranges and larger cohorts are necessary to establish the reliability of P. leucopus as a robust and translatable model for aging studies.
| S-EPMC11335981 | biostudies-literature