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Network analysis of gene expression in mice provides new evidence of involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms

ABSTRACT: To identify potential candidate genes for future pharmacogenetic studies of antipsychotic (AP)-induced extrapyramidal symptoms (EPS), we used gene expression arrays to analyze changes induced by risperidone in mice strains with different susceptibility to EPS This study is a part of a convergent functional genomic approach that plans to integrate the data presented here with: data from gene expression analysis of neuroblastoma cell line under treatment with risperidone; and data from gene expression analysis of peripheral blood from first psychotic patients treated with risperidone.

ORGANISM(S): Mus musculus

PROVIDER: GSE67723 | GEO | 2015/04/09

SECONDARY ACCESSION(S): PRJNA280755

REPOSITORIES: GEO

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Network analysis of gene expression in mice provides new evidence of involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms

Project description:To identify potential candidate genes for future pharmacogenetic studies of antipsychotic (AP)-induced extrapyramidal symptoms (EPS), we used gene expression arrays to analyze changes induced by risperidone in mice strains with different susceptibility to EPS This study is a part of a convergent functional genomic approach that plans to integrate the data presented here with: data from gene expression analysis of neuroblastoma cell line under treatment with risperidone; and data from gene expression analysis of peripheral blood from first psychotic patients treated with risperidone. Gene expression was assessed by microarray (Affymetrix GeneChip® Arrays MG 430 PM) in mice treated with risperidone 1mg/kg for three consecutive days

2015-04-09 | E-GEOD-67723 | biostudies-arrayexpress

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Expression data SK-N-SH cells treated with risperidone

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The Atypical Antipsychotic Risperidone Targets Central Melanocortin 4 Receptors to Cause Weight

Project description:The Atypical Antipsychotic Risperidone Targets Central Melanocortin 4 Receptors to Cause Weight

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The Atypical Antipsychotic Risperidone Targets Central Melanocortin 4 Receptors to Cause Weight

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Microarray profiling of rats treated for 21 days with haloperidol (0.25 mg/kg/d), risperidone (5 mg/kg/d) or vehicle

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