Effect of Age on Gene Expression Profiles in Rhesus Monkey Bone Marrow-Derived Mesenchymal Stem Cells
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ABSTRACT: The objective of this study was to elucidate age-related differences in gene expression profiles of rhesus monkey bone marrow-derived mesenchymal stem cells (rhMSC) obtained from fetal, infant, and adult donors relevant to their growth and other properties. Although a high degree of similarity was observed in the rhMSC gene expression profiles when comparing the three age groups, significant differences were found that strongly parallel gene expression profiles of human MSC. The potential functional relevance of differential gene expression was most apparent when comparing fetal and adult rhMSC transcript profiles. Overall, the observed gene expression profiles are consistent with a loss of rhMSC pluripotency and proliferative capacity with advancing donor age. In addition, these data highlight the importance of use of non-human primates as a model system for studying the properties of human stem cells. Keywords: age of donor
ORGANISM(S): Homo sapiens Macaca mulatta
PROVIDER: GSE6814 | GEO | 2007/01/24
SECONDARY ACCESSION(S): PRJNA99183
REPOSITORIES: GEO
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