Dataset Information

Proteome and phosphoproteome analysis of monkey brains with PINK1 depletion

ABSTRACT: PINK1 protein is highly expressed in primate brains. CRISPR-Cas9-mediated depletion of PINK1in fetal and adult monkey brains causes severe neurodegeneration without affecting mitochondrial proteins and morphology.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Macaca Mulatta (rhesus Macaque)

TISSUE(S): Brain

SUBMITTER: Yunpeng Zhang

LAB HEAD: Liao Lujian

PROVIDER: PXD023520 | Pride | 2022-02-16

REPOSITORIES: pride

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			Action	DRS
	20160602_pink1_mon_Ctx_TMT_TiO_F1.raw	Raw
	20160602_pink1_mon_Ctx_TMT_TiO_F10.raw	Raw
	20160602_pink1_mon_Ctx_TMT_TiO_F10_02.raw	Raw
	20160602_pink1_mon_Ctx_TMT_TiO_F11.raw	Raw
	20160602_pink1_mon_Ctx_TMT_TiO_F11_02.raw	Raw

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Publications

PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis.

Yang Weili W Guo Xiangyu X Tu Zhuchi Z Chen Xiusheng X Han Rui R Liu Yanting Y Yan Sen S Wang Qi Q Wang Zhifu Z Zhao Xianxian X Zhang Yunpeng Y Xiong Xin X Yang Huiming H Yin Peng P Wan Huida H Chen Xingxing X Guo Jifeng J Yan Xiao-Xin XX Liao Lujian L Li Shihua S Li Xiao-Jiang XJ

Protein & cell 20211120 1

In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson's disease (PD). However, difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivo role of PINK1. Here we report that PINK1 kinase form is selectively expressed in the human and monkey brains. CRISPR/Cas9-mediated deficiency of PINK1 causes similar neurodeg ...[more]

PMID: 34800266

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