Proteomics

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Proteome and phosphoproteome analysis of monkey brains with PINK1 depletion


ABSTRACT: PINK1 protein is highly expressed in primate brains. CRISPR-Cas9-mediated depletion of PINK1in fetal and adult monkey brains causes severe neurodegeneration without affecting mitochondrial proteins and morphology.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Macaca Mulatta (rhesus Macaque)

TISSUE(S): Brain

SUBMITTER: Yunpeng Zhang  

LAB HEAD: Liao Lujian

PROVIDER: PXD023520 | Pride | 2022-02-16

REPOSITORIES: Pride

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In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson's disease (PD). However, difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivo role of PINK1. Here we report that PINK1 kinase form is selectively expressed in the human and monkey brains. CRISPR/Cas9-mediated deficiency of PINK1 causes similar neurodeg  ...[more]

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