Replication timing of control and siRNA PR-set7 cells
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ABSTRACT: Although histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains poorly understood. Here, we show that the regulation of histone H4-K20 methylation states, in particular for the monomethylation, is a critical determinant of licensing and time activation of replication origins in mammalian cells.
ORGANISM(S): Homo sapiens
PROVIDER: GSE69083 | GEO | 2016/07/01
SECONDARY ACCESSION(S): PRJNA284499
REPOSITORIES: GEO
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